Kinetics lead-ligand interactions

From the broad range of studies that have been conducted to date on both the kinetics and thermodynamics of lead-ligand interactions, we draw the following conclusions ... 

More studies are needed on the kinetics and thermodynamics of lead-ligand interactions in complex systems (including mixed-phase systems) so that we can better understand lead speciation in vivo and in the environment. 

Metal-ligand interactions are strong and highly directional and lead to the self-assembly of robust stable coordination cages. Kinetically labile metal-ligand (M-L) interactions... 

Very recently, the kinetics and thermodynamics of a variety of axial ligation reactions have been investigated with Fe11 and Co11 porphyrins involving the small molecules CO, 02, and NO as ligands 27-30, 40, 92, 93). These experiments lead to the conclusion that the dynamic trans effects observed in these systems cannot alone be explained by the interaction models D and F (Fig. 1). Especially imidazole and its derivatives do not hold the place in various series of trans effects that they should take on the ground of their proton basicities. Therefore, besides their usual a-donor-tr-acceptor function, these unsaturated molecules are ascribed an additional 7r-donor function. 

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