Kinetic vs. thermodynamic product

The control of kinetic vs thermodynamic product formation can often be achieved by suitable modification of reaction conditions. A far more difficult task is to switch from the formation of a favoured major product to a disfavoured minor product, especially when the transition states for the two processes share most features in common. This challenge has been met by antibodies with considerable success, both for reaction pathways differing in regioselectivity and also for ones differing in stereoselectivity. In both situations, control of entropy in the transition state must hold the key. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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