Kinetic models of whole cell biosensors

Despite their potential importance, there are few analytical models of whole cell biosensing devices—particularly when compared to the plethora of models describing enzyme based biosensors [62]. Although aspects of cellular biochemistry are similar to those of isolated enzymes [63], problems arise in modelling the physicochemistry of whole cells due to their complex nature they are large (typically 0.2-10 jxm) they may contain a variety of biological structures (membranes, organelles, etc.) they incorporate a diversity of biochemical pathways and they may contain many types of active site. 

With respect to whole cell biosensors utilising dissolved oxygen probes, Liang et al. reported a four-layer model to describe the signals from an oxygen probe used to transduce the respiratory activity of mouse leukaemia tumour cells [13]. This work was carried out with a view to using the biosensor to study the dynamic responses to various drugs. Finite difference methods were used to solve the material balances between the inner 

Redox mediated whole cell biosensors for toxicity assessment 

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