Kinetic isotope effects in phosphoryl transfer reactions

KINETIC ISOTOPE EFFECTS IN PHOSPHORYL TRANSFER REACTIONS 

In the case of phosphate monoester hydrolysis by PTPases it has been argued that reported 0 isotope effects for the non-bridge phosphate oxygens, ( max/KTti) o -6ridge show that the reacting groups are unprotonated [44]. However, the 1 )non-bridge values were then corrected, by the isotope effect 

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