Kinases positron emission tomography

Gambhir S S, Bauer E, Black M E, et al. (2000). A mutant herpes simplex virns type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc. Nat. Acad. Sci. USA. 97 2785-2790. 

Shields AP, Grierson JR, Dohmen BM, MachuUa HJ, Stayanoff JC, Lawhom-Crews JM, Obradovich JE, Muzik O, Mangner TJ. Imaging proliferation in vivo with [E-18]ELT and positron emission tomography. Nat Med 1998 4 1334-1336. Sherley JL, Kelly TJ. Regulation of human thymidine kinase during the cell cycle. J Biol Chem 1988 263 8350-8358. 

Cyano-2-fluoropyridines are an important class of biologically active compounds that include potent kinase inhibitors, potassium channel inhibitors, and CNS active agents 51-53 (Fig. 1) [51-55]. In addition, fluorinated pyridines can be potentially used as labeling agents for various spectroscopic techniques such as positron emission tomography, X-ray photoelectron spectroscopy, and NMR spectroscopy. 

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