Kinases high-throughput

Vangrevelinghe E, Zimmermann K, Schoepfer J, Portmann R, Fabbro D, Furet P. Discovery of a potent and selective protein kinase CK2 inhibitor by high-throughput docking. J Med Chem 2003 46 2656-62. 

Rininsland F, Stankewicz C, Weatherford W, McBranch D (2005) High-throughput kinase assays with protein substrates using fluorescent polymer superquenching. BMC Biotechnol 5 16... 

Sills, M.A., Weiss, D., Pham, Q., Schweitzer, R., Wu, X., and Wu, J.J., Comparison of assay technologies for a tyrosine kinase assay generates different results in high throughput screening, /. Biomol. Screen., 7,191, 2002. 

Von, L.A., Kumpf, R., Menzel, S., Reulle, D., Griebel, R., Valler, M.J., and Buttner, F.H., Miniaturization and validation of a high-throughput serine kinase assay using the alpha screen platform, /. Biomol. Screen., 9, 719, 2004. 

Furet et al. described the discovery of a novel, potent and selective kinase CK2 inhibitor by a high-throughput docking protocol [250]. A large subset of the Novartis corporate database with 400 000 compounds was flexibly docked using DOCK 4.01 [93, 117]... 

Minor, L.K. Assays for membrane tyrosine kinase receptors methods for high-throughput screening and utility for diagnostics. Expert Rev. Mol. Diagn. 2005, 5, 561—571. 

Figure 1. Since the mid-1990s, high throughput technologies have rapidly expanded the number of targets that have been expressed and successfully co-crystallized. This figure shows the substantial growth in the number of distinct kinase co-crystals in the public domain (data for plot gathered from the PDB).

Chambers, S. R, Austen, D. A., Fulghum, J. R. and Kim, W. M. (2004). High-throughput screening for soluble recombinant expressed kinases in Escherichia coli and insect cells. Protein Expr. Purif. 36, 40-47. 

Raf kinase inhibitor. High-throughput screening of a chemical collection at the former Bayer Research Center turned up... 

Card, A., Caldwell, C., Min, H., et al. (2009) High-throughput biochemical kinase selectivity assays panel development and screening applications. J Biomol Screen 14(1), 31-42. 

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