Kinase inhibitors hinge binding

Poorly soluble brickdust compounds are not preferentially selected for by HTS as is the case with greaseballs. However, brickdust compounds are extremely common in certain popular current era targets, e.g. the ATP competitive hinge region binding site in protein kinase inhibitors. 

Adenine-binding region (ABR) - all ATP-competitive kinase inhibitors bind in this hydrophobic region and interact with the hinge domain via hydrogen bonds. 

Figure 2.13 Identification of key hinge region binding motifs from kinase inhibitors for consideration as library start points.

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