Kill or Cure - Complexes as Drugs

Introduction to Coordination Chemistry Geoffrey A. Lawrance 2010 John Wiley Sons, Ltd 

Gamma radiolysis contrast agents Magnetic resonance contrast agents 

Blood pressure control Diabetes - insulin mimics Antimicrobials 

Metal-containing coordination compounds that show a capacity to cure or control a disease have grown remarkably in number and range of applications in recent decades. Their form covers a wide range of metal ions, ligands and stereochemistries. Some examples appear in Table 9.1. It is not the role of an introductory text to cover applications in depth, but it is appropriate to illustrate their applications and show how they link with our basic concepts of coordination chemistry. 

Cisplatin acts by binding to DNA and inhibiting replication in the cancer cell. Substitution reactions of coordinated chloride ligands are the key chemistry in reactions of cisplatin in a human cell. Most cisplatin circulates in the blood unchanged over a short timeframe, as 

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