Kidamycins

A key step in the synthesis of the aglycone structures of the altromycins and kidamycin involves activation of the acid 750 with l-chloro-iV,iV-2-trimethyl-l-propenylamine, which results in spontaneous cyclization to form the corresponding chromone in high yield (Equation 302) <20050L3617>. 

During model studies toward kidamycins, K.A. Parker and co-workers developed a methodology for the synthesis of... 

Fredenhagen, A. and Sequin, U., 1985, The structure of some products from the photodegradation of pluramycin antibiotics hedamycin and kidamycin, Helv. Chim. Acta 68, 391-402. 

Hygromycin (28) and epihygromycin (29) have been isolated from Coryne-bacterium equi, a newly isolated bacterium the two isomers could be equilibrated in alkaline solution. Trichoviridin has been shown by chemical and X-ray studies to be the unusual isocyanide diepoxide (30) derived from a cyclo-pentanepolyol. A new antibiotic (Bu-2545) isolated from a Streptomyces strain (H230-5) has been shown to be the lincomycin relative (31). Rubiflavin is a mixture of antibiotics whose main components, rubiflavin A and B, have been identified as desacetylpluramycin (32) and kidamycin (33). ... 

Bis-C-aryl glycosides as model kidamycins are mentioned in Chapter 3, and amino acid analogues of 3-deoxyprumycin are referred to in Chapter 9. Cyclophellitol and its diastereomers are covered in Chapter 18, and the synthesis of intermediates for antibiotics is mentioned in Chapter 24. 

Chemical evidence has confirmed that angolosamine (2,3,6-trideoxy-3-di-methyIamino-D-ar 6mo-hexose) and AA-dimethylvancosamine (2,3,6-trideoxy-3-dimethylamino-3-C-methyl-L-/yjco-hexose) are linked as C-glycosides in the antibiotic kidamycin (347). ... 

Kanamycin A, C3 Kasugamycin, C3 Kaurane, T35 Kaurene, T33 Kawain, Y4 a-kessyl alcohol, T25 a-kessyl glycol, T25 Ketohakonanol, T45 Ketohexoses, C2 Ketopentoses, C2 Ketoses, C2 Ketotetroses, C2 Khellactones, Yl Khivorin, T51 Khusimol, T27 Kidamycin, Cl ... 

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