Key Factors in Granulation Modeling

The modeling of granulation system from a mechanistic perspective inevitably means representing the conservation principles and the constitutive relations that reflect the 

The conservation of mass, energy, momentum, and particle number can be important aspects of granulation modeling. 

Mass conservation is crucial and is the fundamental concept for any granulation system. Key factors here will be solids or slurry feed rates, any out flows, and the addition of binders and additives to the granulation device. Accompanying the mass balance over the device will be the energy balance, from which the intensive property of temperature can be estimated. 

Of particular importance in granulation systems is the factor of particle populations. The particle size distribution within granulation devices is crucial, and there are a number of mechanisms that simultaneously occur in the device depending on the powder properties and operating regime. The challenge is in the description of these mechanisms that occur. The following section outlines those mechanisms that require consideration. Section 3 deals in detail with the development of population balance representations and their variants. 

There are three principal mechanisms that need to be considered. 

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