Ketyl enantioselective process

Hoppe D, Marr F, Bruggemann M (2003) Enantioselective Synthesis by Lithiation Adjacent to Oxygen and Electrophile Incorporation. 5 61-138 Hou Z, Wakatsuki Y (1999) Reactions of Ketones with Low-Valent Lanthanides Isolation and Reactivity of Lanthanide Ketyl and Ketone Dianion Complexes. 2 233-253 Hoveyda AH (1998) Catalytic Ring-Closing Metathesis and the Development of Enantioselective Processes. 1 105-132 Huang M, see Wu GG (2004) 6 1-36... 

A single attempt has been made to induce asymmetry in the intermolecular cross coupling reaction by employing a chiral ligand for the samarium ketyl [56]. Utilizing 2,2 -bis(diphenylphosphinyl)-l,l -binaphthyl (BINAPO) as a chiral ligand, a modest start has been made to develop an enantioselective process. However, in the examples reported to date the method is plagued by low yields and/or moderate stereoselectivities. 

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