Lithiation adjacent

Torn T, Nakamura S (2003) Enantioselective Synthesis by Lithiation Adjacent to Sulfur, Selenium or Phosphorus, or without an Adjacent Activating Heteroatom. 5 177-216 Tunge JA, see Cummings SA (2005) 10 1-39... 

Hodgson DM, Stent MAH (2003) Overview of Organolithium-Ligand Combinations and Lithium Amides for Enantioselective Processes. 5 1-20 Hodgson DM, Tomooka K, Gras E (2003) Enantioselective Synthesis by Lithiation Adjacent to Oxygen and Subsequent Rearrangement. 5 217-250... 

Hoppe D, Marr F, Bruggemann M (2003) Enantioselective Synthesis by Lithiation Adjacent to Oxygen and Electrophile Incorporation. 5 61-138 Hou Z, Wakatsuki Y (1999) Reactions of Ketones with Low-Valent Lanthanides Isolation and Reactivity of Lanthanide Ketyl and Ketone Dianion Complexes. 2 233-253 Hoveyda AH (1998) Catalytic Ring-Closing Metathesis and the Development of Enantioselective Processes. 1 105-132 Huang M, see Wu GG (2004) 6 1-36... 

Beak P, Johnson TA, Kim DD, Lim SH (2003) Enantioselective Synthesis by Lithiation Adjacent to Nitrogen and Electrophile Incorporation. 5 139-176 Behr A, Turkowski B, Roll R, Schdbel R, Henze G (2008) Multiphase Catalysis in Temperatme-Dependent Multi-Component Solvent (TMS) Systems. 23 19-52 Bellemin-Laponnaz S, see Gade LH (2006) 22 117-157 Beller M, see Jacobi von Wangelin A (2006) 18 207-221 Beller M, see Striibing D (2006) 18 165-178... 

In addition to the protected pyrroles mentioned above, the 1-azafulvene dimer formed by Mannich reaction of pyrrole-2-carboxaldehyde with di-methylamine has also been successfully lithiated adjacent to both pyrrole nitrogens (Scheme 10). Reaction with electrophiles and subsequent hydrolysis leads to 5-substituted pyrrole-2-carboxaldehydes in good yield [88TL777 92JOM(423)173]. 

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