Ketorolac structure

CONTENTS Introduction to the Series An Editor s Foreword, Albert Padwa. Preface, Bruce E. Maryanoff and Cynthia A. Maryanoff. Computer Assisted Molecular Design Related to the Protein Kinase C Receptor, Paul A. Wenderand Cynthia M. Cribbs. Chemistry and Biology of the Immunosuppressant (-)-FK-506, Ichiro Shinkai and Nolan H. Sigal. The Development of Ketorolac Impact on Pyrrole Chemistry and on Pain Therapy, Joseph M. Muchowski. Application of Silicon Chemistry in the Corticosteroid Field, Douglas A. Livingston. Hu-perzine A-A Possible Lead Structure in the Treatment of Alzheimers Disease, Alan P. Kozikowski, X.C, Tang and Israel Hanin. Mechanism-Based-Dual-Action Cephalosporins, Harry A. Albrecht and James G. Christenson. Some Thoughts on Enzyme Inhibitors and the Quiescent Affinity Label Concept, Mien Krantz Index. 

Tolmetin and ketorolac are structurally related heteroaryl acetic acid derivatives with different pharmacological features. Diclofenac is a phenylacetic acid derivative that was developed specifically as an anti-inflammatory agent. 

Figure 1 Structures of several anti-infiammatory drugs aspirin (1), difiunisal (2), indomethacin (3), ibufenac (4), ibuprofen (rac-2-(4-isobutylphenyl)propionic acid) (5), flurbiprofen (rac-2-((3-fluoro-4-phenyl)phenyl)propionic acid) (6), fenoprofen (rac-2-(3-phenoxyphenyl)propionic acid) (7), suprofen (rac-2-(4(2-thienyloxo)phenyl)propionic acid) (8), carprofen (rac-2-(6-chloro-9/f-carbazolyl)propionic acid) (9), naproxen (S(+)-2-(6-methoxy-2-naphthyl)propionic acid) (10), dexketoprofen (S(+)-2-(3-benzoylphenyl)propionic acid) (11), flunoxaprofen (5(+)-2-(2(4-fluo-rophenyl)benzoxazol-5-yl)propionic acid) (12), and ketorolac (S(+)-5-benzoyl-2,3-dihidro-lfl)-pyr-rolizine-1-carboxylic acid) (13).

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