Ketones ortholithiation

Attachment to a solid support via a secondary amide linkage allows ortholithiations to be carried out in the sohd phase. After a reaction with an aldehyde or ketone, refluxing in toluene returns the amino-substituted polymer 41 (Scheme 21). ... 

Lithium amides (LiTMP) can give good yields of products resulting from ortholithiation of both ketones and lithium carboxylates. Benzophenone 288, for example, with LiTMP gives a good yield of the ortholithiation-dimerisation product 289.103 In general, however, ketones and aldehydes are best lithiated by the method developed by Comins described in section 2.3.2.1.2. 

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