Ketones ketone synthesis from

Ketones can be prepared by trapping (transmetallation) the acyl palladium intermediate 402 with organometallic reagents. The allylic chloride 400 is car-bonylated to give the mixed diallylic ketone 403 in the presence of allyltri-butylstannane (401) in moderate yields[256]. Alkenyl- and arylstannanes are also used for ketone synthesis from allylic chlorides[257,258]. Total syntheses of dendrolasin (404)f258] and manoalide[259] have been carried out employing this reaction. Similarly, formation of the ketone 406 takes place with the alkylzinc reagent 405[260],... 

The intramolecular ketone synthesis from the chloride of hydro-cinnamic acid ... 

In this section we have seen that fatty acids are oxidized in units of two carbon atoms. The immediate end products of this oxidation are FADH2 and NADH, which supply energy through the respiratory chain, and acetyl-CoA, which has multiple possible uses in addition to the generation of energy via the tricarboxylic acid cycle and respiratory chain. Unsaturated fatty acids can also be oxidized in the mitochondria with the help of auxiliary enzymes. Ketone body synthesis from acetyl-CoA is an important liver function for transfer of energy to other tissues, especially brain, when glucose levels are decreased as in diabetes or starvation. 

Milstein, D., Stille, J. K. A general, selective, and facile method for ketone synthesis from acid chlorides and organotin compounds catalyzed by palladium. J. Am. Chem. Soc. 1978,100, 3636-3638. 

Ketone synthesis from barium salt of a carboxylic acid, 102... 

Benzophen-oae, Diphenylmethanone diphenyl ketone benzoylbenzene. CwHwO mol wt 182.21. C 85.69%, H 5.53%, O 8.78%. CtHsCOCsHj. Prepd by the Friedel-Crafts ketone synthesis from benzene and benzoyl chloride in the presence of ASCI, Marvel, Sperry, Org Syn. call. vol. I (Wiley, New York, 2nd ed., 1941) p 95. By decarboxylation of o-benzoytbenzoic acid in the presence of copper catalyst L. F. Fieser, Organic Experiments (D. C. Heath Co., Boston, 1964) pp 201-203. 

Related to the original Suzuki coupling is the ketone synthesis from acid chloride and trialkyl boranes and thiol esters with arylboronic acids. - The latter procedure is Pd-catalyzed and Cu-mediated. 

Reaction with carbonyl compounds. Such additions are highly diastereose-lective. Since the reagents are hard, they are well suited for addition to enolizable compounds, including j8-diketones and a-phosphonyl ketones. In the ketone synthesis from lithium carboxylates and RLi the presence of CeCl, greatly increases the yields."... 

Ketone synthesis from acid chlorides (Section 18-11)... 

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