Ketohexokinase KHK, fructokinase

Researchers at the University of Florida have proposed targeting ketohexokinase (fructokinase), one of the main enzymes responsible for fructose metabolism, as a therapy for cardiovascular disease, metabolic syndrome and renal diseases.15 They propose that the rise in serum uric acid levels following fructose intake induces metabolic syndrome by inhibiting endothelial NO. The authors suggest that metabolic syndrome and cardiovascular disease can be controlled by inhibiting the enzymes responsible for fructose metabolism. No further drug discovery efforts have been described. 

3 6-Phosphofructo-2-kinase-Fructose-2,6-bisphosphatase (PFK2-FBPase2) 

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