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Ketoconazole selective toxicity

What is it about fungal cells that is different to human cells and allows selective toxicity of antifungal drugs such as amphotericin, ketoconazole and terbinafine ... [Pg.176]

Ketoconazole Blocks fungal P450 enzymes and interferes with ergosterol synthesis Poorly selective interferes with mammalian P450 function Broad spectrum but toxicity restricts use to topical therapy Oral, topical Toxicity and interactions Interferes with steroid hormone synthesis and phase I drug metabolism... [Pg.1063]

Itraconazole Same as for ketoconazole Much more selective than ketoconazole Broad spectrum Candida, Cryptococcus, blastomycosis, coccidioidomycosis, histoplasmosis Oral and IV duration, 1-2 d poor entry into central nervous system (CNS) Toxicity and interactions Low toxicity... [Pg.1063]

FLUCONAZOLE, ITRACONAZOLE, KETOCONAZOLE, VORICONAZOLE (POSSIBLY POSACONAZOLE) VINCA ALKALOIDS -VINBLASTINE, VINCRISTINE, VINORELBINE t adverse effects of vinblastine and vincristine Inhibition of CYP3A4-mediated metabolism. Also inhibition of P-gp efflux of vinblastine Monitor FBCs and watch for early features of toxicity (pain, numbness, tingling in the fingers and toes, jaw pain, abdominal pain, constipation, ileus). Consider selecting an alternative drug... [Pg.566]

See other pages where Ketoconazole selective toxicity is mentioned: [Pg.302]    [Pg.304]    [Pg.419]    [Pg.67]    [Pg.149]    [Pg.67]    [Pg.149]    [Pg.342]    [Pg.20]    [Pg.421]    [Pg.67]    [Pg.263]   
See also in sourсe #XX -- [ Pg.5 , Pg.268 ]



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