Keto arid

Problem 29.11 What a-keto arid is formed on transamination of leucine ... 

One step synthesis o( substrtuted pyridines from a beta keto ester, an aldehyde arid ammonia. 

Problem 29.16 From what amino arid is the- following rt-keto acid derived ... 

An alkaline pH (- pH 11) is desirable in order to achieve high conversion rates increase solubility of L-phenylalanine inhibit enzymes catalysing degradation of L-phenylalanine and formation of byproducts reduce inhibition of the reaction by the keto form of phenylpyruvic arid. 

JOC 47 2820 (1982) (/1-diketones to hydroxy ketones) 50 127 (fi-keto carboxylate), 3411 (fi-diketones to hydroxy ketones) (1985) 51 1253 (2,2-dithioalkan-l-ones), 2795 (a-flooro ketones) (1986) 52192 (fi-keto esters), 256,1141,1359 (fi-keto esters), 2036 (/1-diketones to hydroxy ketones), 2086 (a-acetoxy ketone), 2244 (fi-keto ester), 3223 (cyclic /1-diketones to hydroxy ketones), 4363 (y- arid 5-keto acids) (1987) 53 860, 1969, 2589 (x-keto ester), 4405 (a-acyloxy ketone), 4962 (1988) 54 2238 (/S-diketone to fi-hydroxy ketone), 2274, 3221 (a-diketone to a-hydroxy ketone) (1989) 55 3917 (1990)... 

A polyfunctional organic molecule can contain many different kinds of functional groups, but for nomenclature purposes, we must choose just one suffix. It s not correct to use two suffixes. Thus, keto ester 3 must be named either as a ketone with an -one suffix or as an ester with an -oate suffix but can t be named as an -onoate. Similarly, amino alcohol 4 must be named either as an alcohol i-ol) or as an amine (-amine) but can t properly be named as an olamine. The only exception to this rule is in naming compounds that have double or triple bonds. For example, the unsaturated acid H2C=CHCH2COOH is 3-butenoic arid, and the acetylenic alcohol HC=CCH2CH2CH2CH2OH is 5-hexyn-l-ol. 

Further uses of nitroalkanes are in 1,4-addltions (Michael reaction) to a.p-unsaturated carbonyl compounds arid the like. Recent repoftp deal with transformations of 1,4-nitro ketones, 7, into 1,4-keto aldehydes, 8, and cycllzatlon to cyclopentenones. ... 

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