Kelly-variation

The versatility of the Stille reaction was illustrated in the preparation of all four benzo[4,5]furopyridines [98]. Inter- and intramolecular variations of the reaction were exploited in this work. The alkoxide of 273 underwent a displacement reaction of chloride of 272 to generate 274. Ring closure to afford 275 was accomplished using the Kelly-variation of the Stille reaction. 

P I H I P >. It ean be shown (H. P. Kelly, Phys. Rev. 131, 684 (1963)) that this differenee allows non-variational teehniques to yield size-extensive energies. This ean be seen in the MPPT/MBPT ease by eonsidering the energy of two non-interaeting Be atoms. The referenee CSF is = Isa 2sa Isb 2sb the Slater-Condon rules limit the CSFs in P whieh ean eontribute to... 

Kelly applied this chemistry to the synthesis of cyclosexipyridine 66. This is an example of an intramolecular variation to this method. Masked enal 65 was prepared and treated with the standard reagents. The acidic medium liberated the aldehyde from its acetal protection. This in situ formation of the reactive species, similar to the above example, then undergoes cyclization to the expected pyridine derivative 66. 

Ziegler K, Chadwick OA, Brzezinski MA, Kelly EF (2005a) Natural variations of 6 °Si ratios during progressive basalt weathering. Geochim Cosmochim Acta 69 4597 610... 

Waritz RS, Steinberg M, Kinoshita FK, Kelly CM, Richter WR (1996) Thyroid function and thyroid tumors in toxaphene-treated rats. Regul Toxicol Pharmacol 24 184-192 Weeke J (1973) Circadian variation of the serum thyrotropin level in normal subjects. Scand J Clin Lab Invest 32 337... 

Assinder, D.J., Kelly, M. Aston, S.R. (1985) Tidal variations in dissolved and particulate phase radionuclide activities in the Esk Estuary, England, and their distribution coefficients and particulate activity fractions. Journal of Environmental Radioactivity 2, 1-22. 

In a survey of ambient measurements of hazardous air pollutants, a median formaldehyde concentration of 2.5 ppb was found for a total of 1,358 samples collected at 58 different locations (Kelly et al. 1994). Air samples collected daily in Schenectady, New York, during the months of June through August 1983 had formaldehyde concentrations ranging from 1 to 31 ppb. There was a signifrcant daily variation that... 

Moses, A. M., Chiang, D. Y., Kellis, M., Lander, E. S., and Eisen, M. B. (2003) Position specific variation in the rate of evolution in transcription factor binding sites. BMC Evol. Biol. 3, 19. 

A variation on this model has recently been proposed by Kelly et al. who suggested that the hydroxy group of the Criegee intermediate could not be immobilized in such a mechanism, and that unreasonable steric constraints would be imposed for many of the substrates transformed reported for these enzymes. A new tautomer of the the flavin hydroperoxide was proposed as part of an alternative scheme (lower cycle, Fig. 16.5-16) in which an intermediate trioxane decomposes to yield the lactone and flavin hydrate. 

Bates, T. S., K. C. Kelly, J. E. Johnson and R. H. Gammon (1995) Regional and seasonal variations in the flux of oceanic carbon monoxide to the atmosphere. Journal of Geophysical Research 100, 23093-23101... 

Very recently the validity of Bohr s hypothesis as applied to reactions in heavy elements has been confirmed by John. He has studied the energy variation of the cross section of (a, xn) reactions with Pb and compared the results with cross sections of the p, xn) reactions obtained by Kelly with In... 

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