Keller-Hoehl

Marfey [11], Bruckner and Keller-Hoehl [20], and Bruckner and Gah [21] discussed independently that the resolution of L- and D-derivatives is essentially due to intramolecular H-bonding. Marfey s conclusions were based on the structural features and elution behavior of five amino acid derivatives, while those of Bruckner et al. were based on stmctural features correlated with separation behavior of a large number of derivatives including several chiral variants (as mentioned above) and construction of molecular models. These are briefly described in the following. 

Bruckner, H. and Keller-Hoehl, C., HPLC separation of DL-amino acids derivatized with Af -(5-fluoro-2,4-dinitrophenyl)-L-amino acid amides, Chroma-tographia, 30, 621, 1990. 

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