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Kaolin Mixture with Pectin

Kaolin is practically insoluble in water and organic solvents. It is also insoluble in mineral acids and solutions of alkali hydroxides. Unless sterilized, it may be heavily contaminated with pathogenic microorganisms, such as bacillus anthracis, clostridium tetani and clostridium welchii. It can be sterilized by maintaining the whole at a temperature not less than 160°C for not less than one hour. The primary applieations of Kaolin USP in the pharmaceutical industry are as an adsorbent at eoneentrations of 7.5 to 55%, dusting powders at 25%, and poultices at a level of 53%. Kaolin has also been used as a diluent in tablet and capsule formulations. Kaolin Mixture with Pectin (Gennaro, 1990), an example of a pharmaceutical adsorbent formulation, is shown below. [Pg.419]

Kaolin is distributed worldwide in nature, but is frequently contaminated with impurities, and must be purified for use in pharmaceuticals. It is used alone or as a mixture with pectin. It is of value primarily in the treatment of diarrhea caused by agents capable of being adsorbed, such as diarrhea caused by dysentery or food poisoning. [Pg.406]

The bioavailability of a single 500-mg dose of metronidazole in 5 healthy subjeets was not significantly changed by 30 mL of a kaolin-pectin antid-iarrhoeal mixture. However, a 14.5% reduction in metronidazole bioavailability occurred with 30 mL of an aluminiiim hydroxide/simeticone suspension, and a 21.3% reduction occurred with a single 4-g dose of colestyramine. The clinical importance of these reductions is probably small, and no special precautions seem necessary. [Pg.319]


See other pages where Kaolin Mixture with Pectin is mentioned: [Pg.420]    [Pg.420]    [Pg.642]    [Pg.298]   
See also in sourсe #XX -- [ Pg.420 ]




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