Kaolin Chloroquine

CHLOROQUINE ANTIDIARRHOEAL DRUGS-KAOLIN i chloroquine levels 1 absorption Separate doses by at least 4 hours... 

Kaolin/pectin is an antidiarrheal combination that absorbs fluid, and binds and removes digestive tract irritants. They are used for symptomatic treattnent of diarrhea. Kaopectate (190 mg kaolin/mL and 4.34 mg pectin/mL) is an antidiarrheal agent. By being absorbent, it recovers excess fluid in bowel dysfunction. It is contraindicated in obstructive bowel dysfunction. When used concomitantly, kaolin/pectin may impair absorption of the following drugs antidyski-netics, antimuscarinics (especially atropine), chloroquine. 

The absorption of chloroquine is moderately reduced by magnesium trisilicate and kaolin. Hydroxychloroquine is predicted to be similarly affected. 

Related in vitro studies by the same authors using segments of rat intestine found that the absorption of chloroquine was decreased as follows magnesium trisilicate 31.3%, kaolin 46.5%, calcium carbonate 52%, and gerdiga 36.1%. Gerdiga is a clay containing hydrated silicates with sodium and potassium carbonates and bicarbonates. It is used as an antacid and is similar to attapulgite. ... 

The modest pharmacokinetic interactions between chloroquine and magnesium trisilicate or kaolin are established, but their clinical importance does not seem to have been assessed. One way to minimise any interaction is to separate the dosages of the antimalarials and magnesium trisilicate or kaolin as much as possible (at least 2 to 3 hours) to reduce admixture in the gut. There do not appear to be any studies to see if other antacids behave similarly. 

McElnay JC, Mukhtar HA, D Arcy PF, Temple DJ, Collier PS. The effect of magnesium trisilicate and kaolin on the in vivo absorptionof chloroquine. J Fra MeifTfy (1982) 85,159-63. 

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