Kanamycin Tobramycin

This enzyme [EC 2.7.7.46] catalyzes the reaction of a nucleoside triphosphate with gentamicin to produce a 2"-nucleotidylgentamicin and pyrophosphate (or, diphosphate). The nucleoside triphosphate can be ATP, dATP, CTP, ITP, or GTP. Kanamycin, tobramycin, and sisomicin can also act as the acceptor substrate. The nucleotidyl residue is transferred to the 2-hydroxyl group of the 3-amino-3-deoxy-D-glucose moiety in the acceptor substrate. 

Pregnancy Category D (amikacin, gentamicin, kanamycin, tobramycin). 

Aminohippuric acid Bulk TLC CMA Silica (MeOH- pH 5.0, 12 kV NH4OH-MeOH Char mycin, lividomycin. amikacin, kanamycin. tobramycin, and sisomycin HPLC-OPA derivatization [148] HPLC-PAD [149-151] [1]... 

Aminoglycoside antibiotics contain amino sugars in their structure. Deoxystreptamine-containing members are neomycin, framycetin, gentamicin, kanamycin, tobramycin, amikacin, netilmicin and sisomicin. Both streptomycin and dihydrostreptomycin contain streptidine, whereas the aminocycli-... 

In hypercalcemia, excessive volume depletion, hyponatremia, and hypotension are major risks associated with the use of loop diuretics, and the side effects of hypokalemia, hyperuricemia, and hyperglycemia are always present. Loop diuretics should not be used concurrently with ototoxic aminoglycoside antibiotics (i.e., streptomycin, gentamicin, kanamycin, tobramycin). 

Kanamycin, Tobramycin, Amikacin, Sisomicin, Netiimicin, Spectinomycin... 

The aminoglycosides include amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), neomycin (Mycifradin), netilmicin (Netromycin), streptomycin, and tobramycin (Nebcin). 

The answer is a. (Hardman, pp 1105-1108.) The activity of streptomycin is bactericidal for the tubercle bacillus organism. Other aminoglycosides (e.g., gentamicin, tobramycin, neomycin, amikacin, and kanamycin) have activity against this organism but are seldom used clinically because of toxicity or development of resistance. 

A, amikacin Ap, apramycin B, butirosin D, dibekacin G, gentamicin H, hygromycin I, isepam-icin K, kanamycin L, lividomycin N, netilmicin Ne, neomycin P, paromomycin R, ribostamycin S, sisomicin Sp, spectinomycin St, streptomycin T, tobramycin. 

Recently, Hanessian has reported methods for direct modification of tobramycin. Tobramycin (or nebramycin) differs from kanamycin B only in its 3 -deoxygenation, which makes tobramycin immune from the modification catalyzed by APH(3 ). A library of tobramycin analogs bearing various functionalities at 0-5 was prepared (Scheme 4.23). In general, these tobramycin analogs were less active than tobramycin (Table 4.15). However, compounds 157 and 159 showed activity against P. aeruginosa (ATCC 27853) (MIC = 12.5 fig/mL). 

TABLE 8.1. Stability Constants (log p and pA Values) of Kanamycin B, Amikacin and Tobramycin Complexes with Cu +... 

Jezowska-Bojczuk et al." compared the coordination modes of tobramycin (6) with Cu + with respect to kanamycin B (tobramycin possesses a 3 -H as opposed to the 3 -OH functionality encountered in kanamycin B). The copper complexes of tobramycin formed at various solution pH values were observed to closely resemble those of kanamycin B (Table 8.1). However, the UV-vis spectrum of... 

Of the eight aminoglycosides that are currently used, five are synthesized from different versions of Streptomyces streptomycin (isolated from Streptomyces griseus), neomycin (isolated from Streptomyces fradiae), paromomycin (isolated from S. rimosus), kanamycin (isolated from Streptomyces kanamyceticus), and tobramycin (isolated from... 

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