Kainate activated current, inhibition

CB13 An allosteric non-CBj, non-CBj site on AMPA GLU j receptors with which anan-damide but not WIN55212-2 can interact to inhibit kainate-activated currents (Akinshola etal., 1999a). 

FIGURE 3.4 Effect of endocannabinoids on AMPA glutamate receptor. In Xenopus oocytes expressing the recombinant rat GluIT3 subunit of AMPA receptor, anandamide, 2-arachidonyl glycerol, and noladin ether inhibited kainate-activated currents. The order of potency of the endocannabinoids in inhibiting receptor currents in oocytes was anandamide > 2-arachidonyl glycerol > noladin ether. 

FIGURE 3.5 Percent inhibition of kainate activated current. The similar inhibitory effects of 2-AG and the synthetic endocannabinoid methanandamide are shown in oocytes expressing homomeric GluRl and GluR3 AMPA receptor. The effects of the endocaimabinoids were compared to arvanil and olvanil (vanilloid agonist) effects in the AMPA receptors and expressed as percentage inhibition of receptor currents in oocytes. 

---