KAGAN-HORNER-KNOWLES Asymmetric

HORNER - KNOWLES - KAGAN Asymmetric Hydrogenation Enantnselective hydrogenation of prochirai olefins with chiral Rh catalysts... 

HOLLEMAN Pmacol synthesis 178 HONZL - RUDINGER Peptide synthesis 179 HORNER KNOWLES - KAGAN Asymmetric hydrogenation 180... 

Early work in asymmetric hydrogenation by Knowles [30] and Horner [31] was accompanied hand in hand by important breakthroughs by Kagan [32] and Knowles [33]. Two ligands feature prominently in this regard the tartrate-derived bidentate ligand DIOP (5, Equation 1) [32] and the chiral monophosphine CAMP (8, Equation 2), which can be prepared by resolution with menthol [33]. 

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