K,Tp channel

The sulfonylurea receptor was identified as an adenosine triphosphate (ATP) sensitive potassium (Katp) channel that is present on the (3-cell membrane surface. Closure of these K tp channels causes (3-cell membrane... 

Dipyridamole is also a potent coronary arteriolar vasodilator, perhaps by opening of vascular K tp channels (2). However, the Food and Drug Administration withdrew conditional approval for certain drug products containing dipyridamole, because of a lack of sufficient evidence of effectiveness in the long-term therapy of angina pectoris (3). 

Binds to the regulatory SUR subunit of the K tp channel in pancreatic B-cells and inhibits the channel... 

It has also been shown that atrial natriuretic factor (ANP), nitric oxide, and isosorbide dinitrite, which dilate arteries and increase intracellular cGMP levels, activate K tp channels suggesting the possibility that either elevation of cGMP or stimulation of cGMP-dependent protein kinase could activate K jp channels in smooth muscle (e.g., see Murphy and Bray den,... 

Angiotensin II, vasopressin, and endothelin inhibit K tp channels in cultured coronary artery smooth muscle cells (e.g., Miyoshi et al, 1992). Muscarinic receptor stimulation inhibited K jp channels in smooth muscle cells in urinary bladder through stimulation of protein kinase C (Bonev and Nelson, 1993b). Serotonin, phenylephrine, histamine, and neuropeptide Y also inhibit K jp currents in smooth muscle cells from mesenteric arteries through stimulation of protein kinase C (Bonev and Nelson, 1995). 

New interest has focused on the possibility that ATP-regulated K+ (K tp) channels might be involved in the membrane response to metabolic inhibition (Standen et al., 1989 Daut et al., 1990). These channels are blocked by ATP and activated by nucleoside diphosphates, and thus would be expected to increase their conductance as [ADP]/[ATP] increases, leading to hyperpolarization. This suggests an attractive hy-... 

Reaction of 3-thioxo benzo-l-thia-2,4-diazine 1,1-dioxide 146 with CH3I results in the S-alkylated 7-halo-3-methyl-sulfanyl-4//-benzo-l-thia-2,4-diazine 1,1-dioxide 147, which then serves as a substrate for displacement with amines to afford the 3-(alkylamino) derivatives 148 as potential K tp channel openers (Scheme 10) <2003JME3342, 2005JME4990>. Other halogenated substrates were studied and, notably, when bulky amines were employed in this... 

Horie M, Mizuno N, Tsuji K, Haruna T, Ninomiya T, Ishida H, Seino Y, Sasayama S. Disopyramide and its metabolite enhance insulin release from clonal pancreatic p-cells by blocking K tp channels. Cardiovasc Drugs Ther (2001) 15, 31-9. 

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