K., acid dissociation

Subramanian, M.S. Pai, S.A. Manchanda, V.K. Acid dissociation of some beta dike-tones in mixtures of water and dioxane - A thermodynamic study, Aust. J. Chem. 26 (1973) 85-89. 

K acid dissociation constant of an independent acidic group... 

Schill G and Gustavii K, Acid dissociation constants of morphine, Acta Pharm. Suec., 1, 24-35 (1964). Cited in Perrin Bases Suppl no. 7484. NB Glass electrode was only calibrated at pH = 9.20 at 20 ° C. The values were validated by comparisons with pJCa values for monofunctional morphine derivatives and checked by potentiometric and partitioning (against dichloromethane) experiments. Reported also codeine (8.26) ethylmorphine (8.33) morphine N-methyl bromide (8.83). 

K. acid dissociation constant mi magnetic quantum number... 

The iodation of acetone is catalysed by acids. The catalytic rate constant, has the following values according to the nature of the acid HA (K, acid dissociation constant) ... 

The equilibrium constant for this reaction is called an acid dissociation constant, K-, and is written as... 

The decrease in the acid dissociation constant from K i to tells us that each successive proton is harder to remove. Consequently, H3PO4 is a stronger acid than H2P04, and H2P04 is a stronger acid than HP 04 . 

The principal limitation to using a titration curve to locate the equivalence point is that an inflection point must be present. Sometimes, however, an inflection point may be missing or difficult to detect, figure 9.9, for example, demonstrates the influence of the acid dissociation constant, iQ, on the titration curve for a weak acid with a strong base titrant. The inflection point is visible, even if barely so, for acid dissociation constants larger than 10 , but is missing when is 10 k... 

In the equation for pM, log K appears instead of piC because iCis a formation constant, the reciprocal of the chelate dissociation constant, which is analogous to the acid dissociation constant K. ... 

G. Kortiim, W. Vogel and K. Andrussow, Dissociation Constants of Organic Acids in Aqueous Solution, Butterworths, London, 1961. 

The numerical values of the terms a and p are defined by specifying the ionization of benzoic acids as the standard reaction to which the reaction constant p = 1 is assigned. The substituent constant, a, can then be determined for a series of substituent groups by measurement of the acid dissociation constant of the substituted benzoic acids. The a values so defined are used in the correlation of other reaction series, and the p values of the reactions are thus determined. The relationship between Eqs. (4.12) and (4.14) is evident when the Hammett equation is expressed in terms of fiee energy. For the standard reaction, o%K/Kq = ap. Thus,... 

Customarily, because the term [HgO] is essentially constant in dilute aqueous solutions, it is incorporated into the equilibrium constant Alto give a new term, K, the acid dissociation constant (where K = [HgO]). Also, the term [HjO ] is often replaced by H, such that... 

The starting material undergoes acid dissociation with pKa = 8.9 the reaction proceeds by parallel hydrolysis of acid (k = 4X 10-6 s l) and anion kj = 8x 10-3 s l). Sketch the expected pH profile with numerical scales on the axes. 

Tam, K. Y. Takacs-Novak, K., Multiwavelength spectrophotometric determination of acid dissociation constants. Part II. First derivative vs. target factor analysis, Pharm. Rese. 16, 374-381 (1999). 

Identify each of the following terms (a) hydronium ion, (h) Bronsted theory, (c) proton (Bronsted sense), (d) acid (Bronsted sense), (e) base (Bronstcd sense), (/) conjugate, (g) strong, (h) acid dissociation constant, (/) ionization constant, (/) base dissociation constant, (k) autoionization, (/) pH, and f/w) K .. 

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