JV-Methyl-D-aspartate

Fagg, G.E., Phencyclidine and related drugs bind to the activated JV-methyl-D-aspartate receptor-channels complex in rat membranes, Neurosci. Lett., 76, 221, 1987. 

Haracz J., Belanger S., MacDonall J., Sircar R. Antagonists of JV-methyl-D-aspartate receptors partially prevent the development of cocaine sensitization. Life Sci. 57 2347, 1995. 

Itzhak Y., Stein I. Sensitization to the toxic effects of cocaine in mice is associated with regulation of jV-methyl-D-aspartate receptors in the cortex. J. Pharmacol. Exp. Ther. 262 464, 1992. 

Lu C., Chan S. L., Haughey N., Lee W. T., and Mattson M. P. (2001a). Selective and biphasic effect of the membrane lipid peroxidation product 4-hydroxy-2,3-nonenal on JV-methyl-D-aspartate channels. J. Neurochem. 78 577-589. 

Li L., Murphy T. H., Hayden M. R., and Raymond L. A. (2004). Enhanced striatal NR2B-containing jV-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease. J. Neurophysiol. 92 2738-2746. 

Randic, M., Cheng, G., and Kojic, L. (1995). Kappa-opioid receptor agonists modulate excitatory transmission in substantia gelatinosa neurons of the rat spinal cord. J. Neurosci. 15, 6809-6826. Ransom, R. W., and Stec, N. L. (1988). Cooperative modulation of [3H] MK-801 binding to the jV-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines. 

Riley, R. C., Zhao, Z. Q., and Duggan, A. W. (1996). Spinal release of immunoreactive dynorphin A (l-8) with the development of peripheral inflammation in the rat. Brain Res. 710, 131-142. Rock, D. M., and Macdonald, R. L. (1992). The polyamine spermine has multiple actions on jV-methyl-D-aspartate receptor single-channel currents in cultured cortical neurons. Mol. Pharmacol. 41, 83-88. 

Grass, S., Hoffmann, O., Xu, X. J., and Wiesenfeld-Hallin, Z. (1996). jV -methyl-D-aspartate receptor antagonists potentiate morphine s antinociceptive effect in the rat. Acta Physiol. Scand. 158, 269—273. 

Lynch, D. R., and Guttmann, R. P. (2002). Excitotoxicity Perspectives based on jV-methyl-D-aspartate receptor subtypes. J. Pharmacol. Exp. Ther. 300, 717-723. 

Nakazawa, T., Shimura, M., Endo, S., Takahashi, H., Mori, N., and Tamai, M. (2005). jV-Methyl-D-Aspartic acid suppresses Akt activity through protein phosphatase in retinal ganglion cells. Mol. Vis. 11, 1173-1182. 

Glutamate and Schizophrenia Phencyclidine, jV-methyl-D-aspartate Receptors, and Dopamine—Glutamate Interactions Daniel C. Javitt... 

NM, neuromuscular NMDA,. A-mel hyl-o-aspartate NMDA-Glu-R, jV-methyl-D-aspartate-binding glutamate receptor... 

Quinoxaline 1,4-dioxides possess antibacterial activity, " as well as being fungicides, insecticides, and herbicides. Quinoxaline-2-carboxylic acid 1,4-dioxide has been isolated from cultures of Sireplomyces ambrofaciens and this compound has been shown to have antibiotic properties. Echinomycin, from the quinoxaline-peptide antibiotic family, contains one or more quinoxaline rings and is an antitumor agent. Quinoxaline derivatives are also antagonists at the jV-methyl-D-aspartate (NMDA) receptor of the glycine modulatory site. Poly(phenylquinoxalines) are used as high temperature polymers. 

Pullan. L.M. era/. (1992) Comparison of binding at strychnine-sensitive (inhibitory glycine receptor) and strychnine-insensitive (JV-methyl-D-aspartate receptor) glycine binding sites. Neurosd. Lett. 148. 199-201,... 

Ornstein, P.L., Schoepp, D.D., Arnold, M.B., Leander, J.D., Lodge, D., Paschal, J.W., and Elzey, T., 4-(TetrazolylaIkyl)piperidine-2-carboxylic acids. Potent and selective JV-methyl-D-aspartic acid receptor antagonists with a short duration of action, J. Med. Chem., 34, 90, 1991. 

Fig. 7.9 Generation of JV-acylethanolamine (NAE) and A-acylphosphatidylethanolamine (NAPE) in brain. Phosphatidylcholine (PtdCho) phosphatidylethanolamine (PtdEtn) cannabinoid lecep-torl (CBj-R) JV-methyl-D-aspartate receptor (NMDA-R) tmandamide and 2-arachidonyl-gltcerol not only stimulate CBi-R but also have stabilizing effects on neural membranes. TBI increases the formation of NAE and NAPE. Ai-arachidonylethanolamine stimulate ceramide formation, N-acylethanolamine inhibit ceramidase. Ceramide induces apoptosis. Plus sign indicate stimulation and minus sign indicates inhibition, (f) Indicate increase in levels...

Skolnick, P, Layer, R.T., Popik, P, Nowak, G., Paul, I.A., and TruUas, R. 1996. Adaptation of JV-methyl-d-aspartate (NMDA) receptors following antidepressant treatment implications for the pharmacotherapy of depression. Pharmacopsychiatry 29 23-26. 

JV-methyl-D-aspartic acid (NMDA) receptor, 1373, 1374,4006 antagmiism, 1249 antagmiist, 1246... 

Ndountse, L. X. Chan, H. M. Methylmercury increases JV-methyl-D-aspartate receptors on human SH-SY 5Y neuroblastoma cells leading to neurotoxicity. Toxicology 2008, 249, 251-255. 

Kashiwagi K, Masuko T, Nguyen CD et al (2002) Channel blockers acting at JV-methyl-D-aspartate receptors differential effects of mutations in the vestibule and ion channel pore. Mol Pharmacol 61 533-545... 

Kashiwagi K, Wifliams K, Igarashi K (2007) Anthraquinone polyamines novel channel blockers of JV-methyl-D-aspartate receptors. Amino Acids 33 299-304 Masuko T, Kashiwagi K, Kuno T et al (1999) A regulatory domain (R1-R2) in the amino terminus of the JV-methyl-D-aspartate receptor effects of spermine, protons, and ifenprodU, and structural similarity to bacterial leudne/isoleudne/valine binding protein. Mol Pharmacol 55 957-969 Masuko T, Kusama-Eguchi K, Sakata K et al (2003) Polyamine transport, accumulation, and release in brain. J Neurochem 84 610-617... 

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