Juvenoids Juvenile Hormone Mimics

Hydroprene, a juvenile hormone analog, is registered for use against cockroaches. It has an oral LD50 in rats of 34,000 mg/kg. 

Pyriproxyfen is used for the control of whiteflies, boll weevils, houseflies, mosquitoes, cockroaches, etc. Its oral LD50in rats is 5000 mg/kg. 

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The N-[4-(benzyloxy)benzyl]anilides obtained by DeMilo and Redfern (1979) proved to be highly effective juvenile hormone mimics, though their structure does not reflect even the intention of preparing terpene inspired juvenoids. The most effective member of this class was N-[4-(3-chlorobenzyl)oxy]benzyl-2,6-difluoro-aniline (69). 

Juvenile hormone receptor Juvenoids, fenoxycarb, pryriproxyfen JH mimics... 

Plant secondary metabolites which mimic JH activity appear to be active on a narrow range of host species. What account(s) for this effect The majority of bioassays used last larval instars of P. apterus, O. fasciatus and pupae of T. molitor to test for activity of the juvenoids. Are these the most sensitive insects Six JHs have been identified to date different homologs have been isolated from specific insect orders. Juvenile hormone III appears to be ubiquitous [12, 13] and, in most species, is the only JH present. Juvenile hormone I and II are important in the regulation of metamorphosis and ovarian maturation in Lepidoptera [5] and the bis-epoxide appears to be the principle JH in higher Diptera [20]. Therefore, the nature of the JH in the test insect and the role that it plays in development must be considered in the selection of the bioassay a compound which mimics the action of JH in P. apterus (Hemiptera) is unlikely to be active in a Lepidopteran insect. 

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