Joullie method

Different methods of classification have been proposed in previous review articles (7, 2, 4-6). In this review the compounds will be presented in a way that copes with the plethora of structures that have been isolated in the meantime. It was originally proposed by Joullie and Nutt (6) and comprises three classification steps ... 

Subsequent to Wandless s AAA approach to ustiloxin D being published, Joullie reported a second-generation synthesis. JouUie s second-generation route employed Wandless s method to prepare the p-hydroxydopa residue 30, which as explained earher, is close to perfect. To generate the crucial aUcyl-aryl ether, JouUie developed a novel Cu-promoted coupling of the dopa-derived phenol 31 with a o-serine derived aziridine 32. This reaction proceeds with excellent stereocontrol to generate just one diastereomer of the alkyl-aryl ether adduct 33 (Scheme 6). 

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