Jaundice liver dysfunction sign

Older adults are particularly susceptible to a potentially fatal hepatitis when taking isoniazd, especially if they consume alcohol on a regular basis. Two other antitubercular drugs rifampin and pyrazinamide, can cause liver dysfunction in the older adult. Careful observation and monitoring for signs of liver impairment are necessary (eg, increased serum aspartate transaminase, increased serum alanine transferase, increased serum bilirubin, and jaundice). 

Monitoring At the first symptoms/sign of liver dysfunction (eg, pruritus, dark urine, persistent anorexia, jaundice, right upper quadrant tenderness, unexplained flu-like symptoms) perform laboratory testing. If the patient has laboratory evidence of liver injury of jaundice, stop therapy and do not restart. 

Advise patients to be alert for signs and symptoms of liver dysfunction (eg, jaundice, anorexia, Gl complaints, malaise) and to report them to their doctor immediately if they occur. 

Hepatic complications Perform periodic liver function tests, such as bilirubins, alkaline phosphatase, or transaminases during therapy discontinue at the first sign of hepatic dysfunction or jaundice. 

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