Jaspis wondoensis

Jaspis wondoensis / Poecillastra wondoensis association IC50 = 4.2nM HDAC inhibition 18.6nM DNA methyltransferase inhibition 0.13ug/mL SK-MEL-2 human skin MIC = 4.37ug/mL MRSA... 

Wondosterols A-C are steroidal glycosides obtained from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis, interwoven into one another and difficult to separate, found on the Korean coasts at a depth of 15 m (Ryu et al, 1999). Another association of this kind had already been reported in Korea with the pair Jaspis sp. and Poecillastra wondoensis (Sim, 1998). Most of these compounds are cytotoxic and antifimgal but some of them, such as eryloside F, possess other properties, in particular that of being a platelet antiaggregant. 

Wondonins A and B resemble the above structures but have an imidazole nucleus. They and were isolated from the association of two species Jaspis sp. and Poecillastra wondoensis mentioned above (Shin et al, 2001a). These are two epimers in 1 or 2 of the structure below in proportions similar to 1 to 3. Subsequently, new dimer and trimer analog derivatives were isolated from the same association between the two sponges (Chang et al, 2008). 

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