Jacobsen’s kinetic resolution

One of the most significant discoveries in asymmetric catalysis is without question Jacobsen s kinetic resolution reaction of racemic mono-substituted epoxides with water [131] and other nucleophUes [32,131,132]. The Co-salen complex 142 provides reliable access to a wide range of terminal epoxides in exceptionally high optical purities (> 99 % ee), as well as the corresponding... 

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