Jacobsen’s five criteria

After presenting the criteria for performance evaluation of the three different techniques, we explain their meaning and significance. In the next section, we will comment on the appropriateness of the criteria and the reference points. This discussion relates to coverage of enzyme performance criteria in Chapter 2. Jacobsen and Finney suggest the following five criteria for comparison of performance ( Jacobsen s five criteria ) ... 

Jacobsen s five criteria were picked for a laboratory situation in which a synthetic target compound, sometimes not even optimized for its purpose, was needed quickly and probably just once or at best a few times, and on a laboratory scale. The criteria were not developed for the situation of large-scale, continual production of a narrowly defined but well-known product. One-time laboratory synthesis protocols have to be concerned about instant availability and instant cost of catalysts (usually not under the influence of the user) but re-usability of catalyst and process performance criteria such as volumetric productivity are not and do not have to be considered. For large-scale continual production the situation is often reversed. 

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