Izenamicin

PEROXIDES AND PEROXIDE COMPOUNDS - INORGANIC PEROXIDES] (Vol 18) IzenamicinAl [35834-26-5]... 

Shordy thereafter, the M-4365 complex of six factors (A —A and G —G ), produced by M. capillata (275,276), was reported. From the izenamicin complex of seven factors produced by a M.icromonospora species, three were new fermentation products (277). Many compounds isolated are identical juvenimicin A, M-4365 A2, and izenamicin A are the same as rosaramicin. Stmctures have been proven by chemical interconversions (261,277,278) and microbial transformations (279). 

A more recently synthesized derivative, 3,4 -dideoxy-OMT (MC-352 or YM-17K) was found to exhibit in vitro activity that compared favourably with commercially available macrolides [124-126]. The strong in vitro potencies and broad spectrum of macrolides related to OMT and rosaramicin have fueled many efforts to find derivatives with suitable oral efficacy and favourable preclinical features. In addition, new fermentation-derived members of this group such as cirramycin F-1 and F-2, izenamicin, and M-119-a have been isolated [127-129]. However, no OMT-related macrolide has yet emerged as a successful clinical candidate. 

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