Itano, Harvey

The Human Hemoglobins Their Properties and Genetic Control Harvey A. Itano... 

Serves as president of the American Chemical Society publishes, with Harvey Itano and John Singer, an influential paper on the molecular basis of sickle-cell anemia... 

After World War II Pauling studied sickle cell anemia, and theorized that it was the result of a genetically based defect in the patient s hemoglobin molecules. In 1949 he and Harvey Itano confirmed this theory they had identified what they called a molecular disease, one that could be defined by a molecular abnormality. In 1954 Pauling received the Nobel Prize in chemistry for his research on the chemical bond and its appfication to the elucidation of the structure of complex substances. ... 

Linus Pauling, Harvey Itano, and John Singer apply electrophoresis to differentiate sickle-cell hemoglobin from normal hemoglobin... 

Harvey Akio Itano did not receive his medal as the outstanding student of the Berkeley Class of 1942 at the commencement ceremony because three weeks earlier he had been moved with his family to an... 

Linus Pauling, Harvey A. Itano, S. J. Singer, and Ibert C. Wells ... 

I am indebted to Dr. Harvey A. Itano for his collaboration in work on hemoglobin and for assistance in the preparation of this paper. 

I have been especially interested in the hemoglobinopathies, which are the diseases, including sickle-cell anemia, to which the name molecular disease was first applied. I remember very well the time, some fifteen years ago, when three of my students—Dr. Harvey Itano, Dr. S. J. Singer, and Dr. I. C. Wells, carried out the crucial experiment that showed that sickle-cell anemia is a disease of the hemoglobin molecule. I had made this prediction three years earlier, and Dr. Itano had worked... 

I have introduced the expression orthomolecular medicine to describe one aspect of molecular medicine. In 1949 my oo-workers Harvey Itano, S. J. Singer, and Ibert C. Wells and I published a paper with the title Sicklecell Anemia, A Molecular Disease. In this paper we communicated our discovery that patients with the disease sickle-cell anemia have in their erythrocytes a form of hemoglobin differing from that manufactured by other people. We pointed out that the difference in molecular structure of the hemoglobin manufactured by persons suffering from this disease leads to a difference in properties of the hemoglobin molecules from those manufactured by other people, and that this difference in properties is responsible for the manifestations of the disease. The disease can properly be described as a disease of the hemoglobin molecule, rather than of the erythrocyte itself, and in consequence it may be called a molecular disease. 

Photo 31 Linus Pauling, Prof. Harvey Itano (right), and Prof. S. Jon Singer (left), co-discoverers of the fact that an abnormal form of hemoglobin is the molecular basis of the inherited disease sickle cell anemia (SP 122). The discovery confirmed Pauling s conjecture to this effect and established his broad concept of molecular disease (Chapter 15). Photo taken in 1984. 

A rapid diagnostic test for sickle cell anemia. Blood. The Journal of Hematology 4 (1949) 66—68. (Harvey A. Itano and Linus Pauling). 

Pauling, Harvey A. Itano, S. J. Singer, and Ibert C. Wells). SP 122 [50-13] Sickle cell anemia hemoglobin. Science 111 (1950) 459. (Linus Pauling, Harvey A. Itano, Ibert C. Wells, Walter A. Schroeder, Lois M. Kay, S. J. 

Introduction. In Molecular Genetics and Human Disease, Lytt I. Gardner, ed., Charles C Thomas, Publisher, Springfield, IL, (1961), pp. ix-xi. [61-11] Thalassaemia and the abnormal human hemoglobins. Nature 191 (1961) 398-399. (Harvey A. Itano and Linus Pauling). 

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