Isozymes responsible for

Nakajima, T.. Wang, R.-S., Elovaara, E., Park, S.S., Gelboin, H.V., Hietanen. E. Vainio, H. (1991) Monoclonal antibody-directed characterization of cytochrome P450 isozymes responsible for toluene metabolism in rat liver. Biochem. Pharmacol., 41, 395-404... 

Failure of contraceptive therapy and breakthrough bleeding have been noted repeatedly in patients concurrently taking various enzyme-inducing anticonvulsant drugs (305,314). These include phenytoin, primidone, ethosux-imide, phenobarbital, and carbamazepine. The specific isozyme responsible for metabolic 2-hydroxylation of ethinylestradiol is CYP3A4, which is induced by... 

Duignan DB, Sipes IG, Leonard TB, et al. 1987. Purification and characterization of dog hepatic cytochrome P-450 isozyme responsible for the metaboUsm of 2,2, 4,4 ,5,5 -hexachlorobiphenyl. Arch Biochem Biophys 225 290-303. 

Degawa, M., Hishinuma, T., Yoshida, H., and Hashimoto, Y., Species, sex and organ differences in induction of a cytochrome P-450 isozyme responsible for carcinogen activation Effects of dietary hepatocarcinogenic tryptophan pyrolysate components in mice and rats, Carcinogenesis, 8, 1913, 1987. 

Huskey, S.-E.W. Dean, D.C. Miller, R.R. Rasmusson, G.H. Chiu, S.-H.L. Identification of human cytochrome P450 isozymes responsible for the in vitro oxidative metabolism of finasteride. Drug Me-tab.Dispos., 1995, 23, 1126-1135... 

Metabolic stability assays can also be utilized to perform CYP reaction phenotyping, namely the identification of specific CYP isozymes responsible for the metabolic reaction [74], Two approaches are commonly used to perform reaction phenotyping by metabolic stability assays. One approach tests the metabolic stability of NCEs in individual human recombinant CYP enzymes, whereas the other incubates NCEs with regular human liver microsomes (HEM) along with specific inhibitors for each isozyme. The reaction phenotyping results are useful in determining whether the test compounds are substrates of specific CYP isozymes, and therefore, whether they are likely to be susceptible to DDIs mediated by those isozymes. 

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