Isothiazoles, aryl

The isothiazole ring causes deactivation of phenyl substituents, particularly in 3-phenyl-isothiazoles. Nitration of arylisothiazoles, however, occurs only in the benzene ring, the pattern of substitution varying greatly with the position of the aryl group on the isothiazole... 

Isothiazole, 4-aryl-3-hydroxy-5-mercapto-methylation, 6, 160 synthesis, 6, 166... 

In the last ten years extensive studies of homolytic arylation have been made in the following heterocyclic series furan, thiophene, thiazole, isothiazole, pyrazole, imidazole, ... 

Isothiazole-5-carboxylic acid, 3-aryl-4,5-dihydro-esters, 6, 165... 

Treatment of aryl and heteroaryl o-azidocarbaldehydes with bis(trimethylsilyl)sulfide and hydrochloric acid gave fused isothiazoles, via thionation of the formyl function followed by spontaneous decomposition at room temperature. Yield was dependent upon the nature of the heteroaromatic ring. [94CL1873, 94PS479]... 

The treatment of a variety of 2-aryl substituted isothiazolo[5,4-6]pyridin-3-ones (210) with sodium hydroxide in refluxing ethanol for 15 min cleaved the isothiazole ring and gave the pyridines (211) in yields ranging from 60-70% <88JHC23>. 

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