Isothiazoles, acetyl preparation

Acetyl- and 5-formylisothiazoles are readily available from 5-lithioisothiazoles.71,102 However, 3-methyl-4-nitroisothiazole does not form a lithium derivative,72 and 4-formyl-3-methyl-4-nitro-isothiazole was prepared by reduction of the appropriate acid chloride with lithium tri-Lbutoxyaluminum hydride.140 A 5-formyl-4-hydroxy-isothiazole has been prepared by direct ring synthesis [Eq. (12)].29... [Pg.30]

Formyl- and 4-bromo-3-formyl-isothiazole have been prepared in good yield from the dibromomethyl compounds obtained by side-chain halogenation of the appropriate 3-methylisothiazole with N-bromosuccinimide. 3-Acetyl- and 3-acetyl-4-bromo-isothiazole have been prepared from the 3-cyanoisothiazoles and methyl magnesium iodide. ... [Pg.119]

See also in sourсe #XX -- [ Pg.108 , Pg.109 , Pg.110 , Pg.114 , Pg.115 , Pg.116 , Pg.117 , Pg.118 , Pg.119 ]

See also in sourсe #XX -- [ Pg.108 , Pg.109 , Pg.110 , Pg.114 , Pg.115 , Pg.116 , Pg.117 , Pg.118 , Pg.119 ]

See also in sourсe #XX -- [ Pg.108 , Pg.109 , Pg.110 , Pg.114 , Pg.115 , Pg.116 , Pg.117 , Pg.118 , Pg.119 ]

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