Isopropylamino-naphthyloxy-propanol

Propranalol hydrochloride (5-l-isopropylamino-3-(l-naphthyloxy)-2-propanol HCl) [4199-10-4] M 295.8, m 192°, 193-195 , [a] +25° (c 1, EtOH) pK 9.5. See preceding entry for physical properties. The is the active isomer which blocks isoprenaline tachycardia and is a (i-adrenergic blocker. [Leclerc et al. Trends Pharmacol Sci 2 18 7987 Howe and Shanks Nature 210 1336 7966.]... 

Chemical Name l-(isopropylamino)-3-(l-naphthyloxy)-2-propanol Itydrochloride Common Name —... 

Propranolol is chemically a naphthol derivative (dl-(isopropylamino)-3-(l-naphthyloxy)-2-propanol). It is a racemic mixture, and the laevo form is the active P-adrenergic blocking agent [10]. After oral administration, it is completely absorbed [11]. However, the systemic availability is relatively low with considerable variation in plasma levels [12,13]. The hepatic extraction of propranolol is about 80- 90%, and thus the main route of drug elimination is via hepatic metabolism [14]. One of the maj or metabolites of propranolol is 4-hydroxypropranolol, and the half-life has been reported to be 3 l-l/2h [15-18]. Since the drug is rapidly metabolized after oral administration, it necessitates a multiple dosage after oral strict patient compliance. 

Isopropylamino-3-(1 -naphthyloxy) propan-2-ol-hydrochloride 2-Propanol, methylethyl) amino]-3-(l-naphthalenyloxy)-hydrochloride BR, USR ... 

Synonyms Inderal DL-propranolol hydrochloride DL-i-(isopropylamino)-3-(i-naphthyloxy)-2-propanol hydrochloride Inderal LA Deralin... 

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