Isomerizations of transitory complexes

ISOMERIZATION OF TRANSITORY COMPLEXES AND STABLE ENZYME FORMS... 

The isomerization of a transitory conplex does not affect the algebraic form of the velocity equation in the absence or in the presence of products, but the composition of some kinetic constants are changed by introducing the rate constants for isomerization k and jtff in the forward dii on and and k in the reverse direction. The isomerization of transitory complexes is very common in many enzyme reactions, particularly among pyridine-dependent dehydrogenases. 

The greatest value of above calculations is in discovering isomerizations of transitory complexes, for which this is really the only available method. 

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