Isolated tissues and organelles

Calculations of ATP utilization rate based on heat dissipation (Table 2) estimated the depressions in metabolism to be 30% (nitrogen) and 42% (pharmacological anoxia) compared to normoxic controls. Even larger 

Comparison of heat flux and ATP utilization in mrtle cortical slices [after 83] 

Similar calorimetric results to those reported for turtle cortical slices have been obtained for telencephalic slices from crucian carp [87]. In response to anoxia, heat flux decreased by 37%, which corresponded to a 31 % fall in ATP 

Whereas phosphorylation efficiency dropped during ADP limitation under normoxia, P 0 ratios were conservatively five-fold higher under severe hypoxia, when oxygen consumption was limited by oxygen supply. A reduction in proton leakage across the inner membrane under hypoxia could potentially explain the observation, which would decrease state 4 respiration. The proton permeability of the inner mitochondrial membrane is dependent on the physical properties of 

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