Isoindoline toxicity

Isoindoline pigments do not exhibit acute toxicity in animal tests by oral and inhala-tive administration. Tests have shown that they do not cause irritation of the skin or mucous membranes. The Ames test for mutagenicity gave negative results, and the test for genotoxicity shows no clastogenic effects. [Pg.229]

Isoindoline pigments are sparingly soluble in water. They exhibit practically no toxicity to fish. The pigments are not biodegradable, but since they are also not... [Pg.229]

Hayashi K, Takahata M, Kawamura Y, Todo Y (2002) Synthesis, antibacterial activity, and toxicity of 7-(isoindolin-5-yl)-4-oxoquinoline-3-carboxylic acids discovery of the novel des-F(6)-quinolone antibacterial agent garenoxacin (T-3811 or BMS-284756). Arzneimittel-Forschung 52 903-913... [Pg.588]

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