Isoindole synthesis

Benz-7-azabicyclo[2.2.1]heptenes in isoindole synthesis, 4, 351 Benz[e][l, 2]azaborine, 2-chloro-1,2-dihydro-synthesis, 1, 647... 

Benzene, o-dibenzoyl-isoindole synthesis from, 4, 330 Benzene, diethynyl-polymerization, 1, 295 polymers... 

Benzimidazolo[l,2-c]thiatri azoles synthesis, 6, 612 Benz[cd]indazole antiaromaticity, 5, 208 Benz[cd]indazole, dihydroaromaticity, 5, 208 Benz[e]indolizine synthesis, 4, 466 Benzipiperylon biological activity, 5, 296 Benz[/]isoindoles synthesis, 4, 266... 

Benzylamine, o-chloro-N-(cyanomethyl)-N-methyl-isoindole synthesis from, 4, 323 Benzylisoquinoline alkaloids synthesis, 1, 446 Benzynes... 

Bond formation through carbanions of type B has been much more widely used. A versatile isoindole synthesis (Scheme 24a) proceeds through intramolecular carbanion addition to an aryne. The subsequent aromatization is effected by base promoted elimination of hydrogen cyanide (77T2255). 

A number of heterocyclics such as coumarins, flavones, and quino-lones have been prepared from o-subst. co-(methylsulfinyl)aceto-phenones . A simple isoindole synthesis with hydrazines has been published Phenolic coupling with PdCl2 has been used efficiently to produce carpanone whereby five contiguous asym. centers with the correct stereochemistry have been introduced in a single step . A facile synthesis of the tetracyclic skeleton of rheadan alkaloids, whidi have a characteristic azepine ring, has been reported Benzimidazoles and benzoxazoles have been prepared by a novel ring closure of a-amino-/9,7-ethylenenitriles . ... 

Dyker provided two examples of the isoindole synthesis based on a transition metal-catalyzed 5-exo-dig cyclization. Thus orfho-alkynyl benzylamines 299 were cydoi-somerized into the isoindole-l-carboxamides 300 in the presence of Au(III)-catalyst, providing the corresponding products in modest yields (Scheme 9.103) [276]. A... 

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