Isocyano-isocyanates Isocyanato-isocyanides

A novel and unique class of orthogonal divalent compounds has recently been filed for European patent application, namely isocyano-isocyanates [1288]. 

The isocyano-isocyanates 1752a-d can easily be prepared in yields of 50-78% by parallel reaction steps in a one-pot synthesis from monoformyldiamines 1751a-d 

As an example supporting the above statements regarding parallel reaction steps, parallel reactions of isocyano-isocyanate 1752b at both the isocyano and iso-cyanato groups can be accomplished in a one-pot procedure, whereby methanol is added to the isocyanato group and a Passerini three-component reaction (P-3CR) with benzaldehyde and acetic acid occurs at the isocyano group, simultaneously affording both the urethane and Passerini product moieties in l-N-(0-methyl-carbamato)-10-N -[(2-acetoxy)-3-phenylacetamido]decane 1753 in 92% yield [1289]. 

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