Isocyanides imidate synthesis

Alternatively, starting this time from aryl isocyanides, the secondary amide can be activated by conversion into an imide by the treatment with B0C2O [29, 38,41]. This strategy was employed in the synthesis of compounds 15,17 and 19 [29], and is particularly appropriate for solid-phase library synthesis. 

Imidates, rearrangement of, 14, 1 Imines, additions of allyl, allenyl, propargyl stannanes, 64, 1 additions of cyanide, 70, 1 as dienophiles, 65, 2 synthesis, 70, 1 Iminium ions, 39, 2 65, 2 Imino Diels-Alder reactions, 65, 2 Indoles, by Nenitzescu reaction, 20, 3 by reaction with TosMIC, 57, 3 Ionic hydrogenation, 71, 1 Isocyanides, in the Passerini reaction, 65, 1... 

Whitby and co-workers developed general methods for the synthesis of ami-dines (129) [78] and imidates (130) [79] by palladium-catalyzed three-component reactions without using an organometallic reagent as coupling partner [Scheme 5.38, reactions (a) and (b)]. Using an excess of isocyanide, conditions were established for the synthesis of a-iminoimidates [Scheme 5.38, reaction (c)] [80]. The use of a bidentate ligand was found to be important for the success of these reactions. 

G. Qiu, Y. Lu, J. Wu, Org. Biomol. Chem. 2013, 11, 798-802. A concise synthesis of 4-imino-3,4-dihydroquinazolin-2-ylphosphonates via a palladium-catalyzed reaction of carbodi-imide, isocyanide, and phosphite. 

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