Triphosgene isocyanides from

Isocyanides from N-formylated amino acid tert-butyl esters, such as For-Gly-OtBu, For-Leu-OtBu 1554, and For-Phe-OtBu, are obtained in good yields (79-94%) by their dehydration with triphosgene at room temperature within 1.5-3 h [53, 1182]. 

Dehydration.. Synthesis of isocyanides from formamides (eq 6) is the only example of a dehydration reaction reported for triphosgene to date. ... 

Ruijter and coworkers elegantly combined stereoselective MCR chemistry with biocatalysis to obtain telaprevir 47, which is a pharmaceutical drug (Incivek or Incivo ) for the treatment of hepatitis C (Scheme 6.4) [21]. In the fu-st step, a Passerini three-component reaction gives access to form 42, which is, upon treatment with NMM (A-methyhnorpho-line) and triphosgene, converted to isocyanide 43. The latter further reacts with the pyrroUne derivative 45 (arose from the desymmetrization of the 3,4-disubstituted meso-pyrro-lidine with monoamine oxidase-N (MAO-N, derived from... 

---