Isocyanatocarboxylic acid esters

N,N,0-tris(carbamyl)-hydroxylamines 26, 293 Isocyanatocarboxylic acid esters... 

The imidazolide group at the amino end of an amino acid is as reactive toward nucleophiles as the imidazolide group at the carboxylic end of an amino acid. If an N-protected amino acid is selected as nucleophile, this method can also be used for peptide synthesis. The amino-activated amino acids, for example N-( 1 -imidazolylcarbonyl)-amino acid esters, are prepared from a-isocyanatocarboxylic acids and imidazole. 

Trimethylchlorosilane/triethylamine Isocyanatocarboxylic acid silyl esters from aminocarboxylic acids via aminocarboxylic acid silyl ester hydrochlorides and carbophenoxyaminocarboxylic acid silyl esters... 

Temporary protection of a-amino acid facilitates certain transformations, includii isocyanate. Thus, Fmoc-derivatives of t a-isocyanatocarboxylic esters on reaction When de-Af-(f-butoxycarbonylation 1 is cat Selective reaction of the primary amm trimethylsilylation of both has been demot still derivatizable. 

Temporary protection of a-amino acids (and A-derivatives) as trimethylsilyl esters facilitates certain transformations, including conversion of the free amino group to an isocyanate. Thus, Fmoc-derivatives of oi-amino esters undergo elimination to give a-isocyanatocarboxylic esters on reaction with MejSiCl-Et N. ... 

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