Isocyanates with 2-imino-4-thiazolines

Treatment of 2-imino-3-phenyl-4-amino-(5-amido)-4-thiazoline with isocyanates or isothiocyanates yields the expected product (139) resulting from attack of the exocyclic nitrogen on the electrophilic center (276). Since 139 may be acetylated to thiazolo[4,5-d]pyrimidine-7-ones or 7-thiones (140). this reaction provides a route to condensed he erocycles (Scheme 92). 

Reaction of 2-imino-3-alkyl-4-thiazolines with alkyl isocyanates gives the ureas (382), which when nitrated on C-5 give the schistosomicide class of compounds (383) (Scheme 219), When nitration takes place on the ring... 

Isocyanate, Me, 431 phenyl, 431 Isocyanates, 58 acyl isocyanates, 92 alkyl isocyanates, 92, 118 aryl versus alkyl, 118 with hydrazinothiazoles, 100, 106 with 2-imino-4-thiazolines, 125 to mesoionic compounds, 65 to thiazolyl urea, 58, 92 Isoindolenine derivative, 56 Isomerism, E-Z equilibrium, 23 Isomerization, catalyst in aji-unsaturated acids, 438... 

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See also in sourсe #XX -- [ ]

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