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Isoaminile

The citrate salt of isoaminile [77-51-0] (50) is a nitrile used as an antitussive in numerous European countries. In clinical trials it was shown to be as effective as codeine or chlophedianol, with few mild side effects. Isoaminile citrate is longer acting than chlophedianol and does not cause the respiratory depression of codeine (68). [Pg.525]

Replacement of one of the phenyl groups by an alkyl group of similar bulk, on the other hand, alters the biologic activity in this series. Alkylation of phenylacetonitrile with isopropyl bromide affords the substituted nitrile, 136. Treatment of the anion prepared from 136 with strong base with 2-dimethylamino-l-chloropropane gives isoaminile (137). It is of note that alkylation of this halide, isomeric with that used in the early methadone synthesis, is apparently unaccompanied by isomer formation. Isoaminile is an agent with antitussive activity. [Pg.82]

Cj H7N 140-29-4) see Azatadine Dicycloverine Disopyramide Ethoheptazine Isoaminile Levocabastine Mephenytoin Methylphenidate Methylphenobarbital Milnacipran hydrochloride Oxeladin Pentapiperide Pentoxyverine Pethidine Phenglutarimide Pheniramine Phenobarbital Tolazoline Triamterene Valethamate bromide 1 -benzy l-4-cyanopiperidine (C]3H 9N2 62778-37-4) see Ketanserin... [Pg.2304]

C7H7CI 75-29-6) see Gallopamil Isoaminile Verapamil isopropyl chloroacetate... [Pg.2404]

C H,jN 555S-29-2) see Isoaminile 6-methyl-4-phenyl-3,4-dihydro-2H-l-benzopyran-2-one (C (jH 402 40546-94-9) see Tolterodine... [Pg.2420]

Indomethacin, 318 Insulin, in diabetes, 136 lodination of phenols, 97, 314 lodothiouracyl, 265 Iprindol, 318 Iproniazid, 254 Isoaminile, 82 Isobucaine, 12 Isocarboxazine, 233... [Pg.482]

Isoaminile Citrate 455.5 Butethamate Citrate 479.0 Clobetasone Butyrate... [Pg.1082]

See other pages where Isoaminile is mentioned: [Pg.440]    [Pg.270]    [Pg.239]    [Pg.840]    [Pg.1629]    [Pg.1692]    [Pg.1719]    [Pg.1740]    [Pg.1099]    [Pg.1099]    [Pg.2362]    [Pg.459]    [Pg.1587]    [Pg.1957]    [Pg.1957]    [Pg.1099]    [Pg.2362]    [Pg.2420]    [Pg.136]    [Pg.145]    [Pg.686]    [Pg.686]    [Pg.687]    [Pg.1076]    [Pg.1085]    [Pg.1097]    [Pg.1101]    [Pg.1103]    [Pg.1113]    [Pg.1130]   
See also in sourсe #XX -- [ Pg.82 ]

See also in sourсe #XX -- [ Pg.82 ]

See also in sourсe #XX -- [ Pg.1099 ]

See also in sourсe #XX -- [ Pg.245 ]

See also in sourсe #XX -- [ Pg.149 ]



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Isoaminile citrate

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